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  • Title: Transport-associated phosphorylation of 2-deoxy-D-glucose in Saccharomyces fragilis.
    Author: Jaspers HT, van Steveninck J.
    Journal: Biochim Biophys Acta; 1975 Oct 17; 406(3):370-85. PubMed ID: 1182170.
    Abstract:
    2-Deoxy-D-glucose transport and metabolism was studied in Saccharomyces fragilis. Inside the cells four phosphorylated and three non-phosphorylated derivatives were found and identified. Accumulation of phosphorylated 2-deoxyglucose derivatives was balanced by a concomitant decrease of cellular ATP, orthophosphate and polyphosphates. The free sugar was concentrated against a concentration gradient, contradiciting facilitated diffusion. Pulse labeling experiments revealed transport-associated phosphorylation. Theoretical considerations and analysis of the effects of iodoacetate showed that an intracellular hexokinase activity was not involved in 2-deoxyglucose phosphorylation, although this sugar is a good substrate for the enzyme in in vitro experiments.
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