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  • Title: Anticonvulsant activity of reaction products of 5,5-diphenylhydantoin with substituted methylene bromides.
    Author: Usifoh CO.
    Journal: Arch Pharm (Weinheim); 2001 Nov; 334(11):366-8. PubMed ID: 11822175.
    Abstract:
    Some derivatives of 5,5-diphenylhydantoin (phenytoin) were synthesized by the alkylation of phenytoin with substituted methylene bromides. The hydantoins were evaluated for possible anticonvulsant activity in the maximal electroshock (MES)- and subcutaneous pentylenetetrazole (ScMet)-induced seizures and for neurotoxicity in the rotorod test in mice and rats.
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