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  • Title: [Thyroxine depression of compensatory hypertrophy of the thyroid gland in rats of different ages].
    Author: Bershteĭn LM.
    Journal: Biull Eksp Biol Med; 1975 Aug; 80(8):31-3. PubMed ID: 1182302.
    Abstract:
    It was shown on hemithyroidectomized male rats (2--2.5, 8--10 and 14--16--month-old) that with the advance of age there occurred an increase in the inhibitory effect of the same (as per 100 g of body weight) dose of the exogenous thyroxine on the thyroid compensatory hypertrophy. It is supposed that the threshold of hypothalamo-pituitary-thyroid system to homeostatic inhibition decreased with ageing.
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