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  • Title: Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent.
    Author: Massari P, Henneke P, Ho Y, Latz E, Golenbock DT, Wetzler LM.
    Journal: J Immunol; 2002 Feb 15; 168(4):1533-7. PubMed ID: 11823477.
    Abstract:
    The immunopotentiating activity of neisserial porins, the major outer membrane protein of the pathogenic Neisseria, is mediated by its ability to stimulate B cells and up-regulate the surface expression of B7-2. This ability is dependent on MyD88 and Toll-like receptor (TLR)2 expression, as demonstrated by a lack of a response by B cells from MyD88 or TLR2 knockout mice to the porins. Using previously described TLR2-dependent reporter constructs, these results were confirmed and were shown to be due to induction of NF-kappaB nuclear translocation. This is the first demonstration of known vaccine adjuvant to stimulate immune cells via TLR2.
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