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  • Title: [Influence of transjugular intrahepatic portosystemic stent shunts on portal and systemic hemodynamics of patients with portal hypertension].
    Author: Wu X, Li J, Cao J, Wu X, Ni X.
    Journal: Zhonghua Wai Ke Za Zhi; 1998 Jun; 36(6):342-4. PubMed ID: 11825406.
    Abstract:
    OBJECTIVE: To determine the influence of transjugular intrahepatic portosystemic stent shunts (TIPSS) on portal and systemic hemodynamics of patients with portal hypertension. METHODS: Fifteen patients who had undergone TIPSS with 10 mm stents were studied. The parameters of portal, systemic and pulmonary hemodynamics were measured with Doppler sonography, direct portal pressure measurement, blood-gas analysis and Swan-Ganz catheter before and 30 min and 2 weeks after TIPSS. RESULT: Portal pressure decreased by 34% and 55.4%, and PO(2), SatO(2) increased by 67.7%, 21.3% and 68%, 20.4% respectively 30 min and 2 weeks after TIPSS. Portal blood velocity increased by 1.4 times 2 weeks after TIPSS. CO, CI, SI increased (P < 0.01) and SVR, PVR decreased (P < 0.01) after TIPSS. Also, RAP, PAP increased (P < 0.05). Renal blood flow increased (P < 0.01) and renal function significantly improved. CONCLUSION: TIPSS can not only decrease portal pressure and improve renal function, but also worsen portal and systemic hemodynamics. Cardiac and liver function should be monitored before and after TIPSS.
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