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  • Title: [Intrahepatic portal vein compliance in cirrhosis].
    Author: Zheng E, Leng X, Liu J, Xu Q, Peng J, Du R.
    Journal: Zhonghua Wai Ke Za Zhi; 1998 Jun; 36(6):350-2. PubMed ID: 11825409.
    Abstract:
    OBJECTIVE: To elaborate the effects of increase in portal flow on intrahepatic vein compliance with isolated perfused cirrhotic model (IPCM). METHOD: Cirrhosis was induced by CCl(4) in 80 Wistar rats, which were divided into two groups A and B, by portal with/without hepato-artery. Portal flow was increased and hemodynamic parameters were recorded and analysed. RESULT: In group A, compared with 1.65 +/- 0.28 kPa at basal control, portal pressure was elevated from 2.55 +/- 0.40 kPa to 3.96 +/- 0.67 kPa. Q(35)-Q(55) flow rates were raised from 35 to 55 ml/min, respectively. A correlation existed between portal flows and pressures (r = 0.985, P < 0.01). The low flow rate of 15 ml/min at Q(15) caused a irreversible model injury. A largest flow rate in IPCM was, less than in IPRL. In group B, no low flow-injury was found. CONCLUSION: Portal vein compliance of liver is decreased markedly in cirrhotic portal hypertension, but hepatic flow is increased. There are likely some compensative relations between portal and hepato-arterial system.
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