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  • Title: [Morphometrical study on inhibitory effect of vitamin B6 and banana-stem extract on calcium crystallization].
    Author: Li S, Wu C, Nong H, Deng Y.
    Journal: Zhonghua Wai Ke Za Zhi; 1998 Dec; 36(12):763-5. PubMed ID: 11825520.
    Abstract:
    OBJECTIVE: To search for the anticrystallization mechanism by vitamin B(6) and banana stem extract. METHOD: Thirty-six male China-1 mice were divided into 4 groups: normal, crystallization, vitamin B(6) and banana-stem extract groups. Calcium oxalate crystallization was induced by 1% glycol and 1% ammonium chloride in the last 3 groups. Vitamin B(6) was then given to the 3rd group and banana stem extract to the 4th group for 3 weeks. At the end of 3 weeks, all the mice were sacrificed and the kidneys were taken for morphometrical studies using image analysis system and assayed for calcium oxalate. RESULT: Morphometrical area density and numerical density of crystallization was significantly less in the vitamin B(6) group and the banana-stem extract group as compared with the crystallization group, being the least in the banana-stem extract group. Oxalate in renal tissue was also significantly reduced. Both vitamin B(6) and banana stem extract had no effect on renal tissue calcium. CONCLUSION: Vitamin B(6) and banana-stem extract may be useful agents in the treatment of patients with hyperocaluric urolithiasis.
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