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  • Title: Molecular mycology: a genetic toolbox for Histoplasma capsulatum.
    Author: Magrini V, Goldman WE.
    Journal: Trends Microbiol; 2001 Nov; 9(11):541-6. PubMed ID: 11825714.
    Abstract:
    Research in medical mycology has traditionally been a mix of exciting biology and frustrating genetics, although the excitement has been steadily increasing as genetic obstacles have been successfully overcome. Now, a variety of fungal pathogens can be studied using molecular techniques derived from classical bacterial and yeast genetics, but with selective and strategic adaptations. Histoplasma capsulatum is the best-studied of the primary pathogens known as 'dimorphic' fungi, and tailored molecular genetic strategies are beginning to reveal a repertoire of genes and gene products intimately associated with pathogenesis.
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