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  • Title: Recombinant follicle-stimulating hormone stimulates ovarian androgen synthesis in down-regulated ovulatory women.
    Author: Tanbo T, Dale PO, Abyholm T.
    Journal: Gynecol Endocrinol; 2001 Dec; 15(6):407-12. PubMed ID: 11826763.
    Abstract:
    In order to study androgen secretion during controlled ovarian hyperstimulation for in-vitro fertilization-embryo transfer, an open randomized study comparing the response to recombinant or urinary follicle-stimulating hormone (FSH) in down-regulated cycles was performed. During FSH administration significant increases in testosterone, androstenedione and dehydroepiandrosterone sulfate (DHEAS) levels were observed. During the same period a slight decrease in luteinizing hormone (LH) levels was seen. At all times during the stimulation period a significant correlation between estradiol and testosterone or androstenedione levels was observed. We conclude that FSH, through granulosa derived paracrine factors, initiates thecal androgen synthesis and secretion.
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