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  • Title: SW-163A and B, novel immunosuppressants produced by Streptomyces sp.
    Author: Takahashi K, Tsuda E, Kurosawa K.
    Journal: J Antibiot (Tokyo); 2001 Nov; 54(11):867-73. PubMed ID: 11827027.
    Abstract:
    SW-163A and B, novel immunosuppressants, were isolated from the culture broth of Streptomyces sp. SNA15896. The molecular formulas of SW-163A and B were determined as C34H42N2O12 and C33H40N2O12 based on the HRFAB-MS analysis, respectively. Both compounds were elucidated to be a large ring ester structure through spectroscopic analyses including various NMR measurements. SW-163A and B showed immunosuppressive and antimicrobial activities in vitro.
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