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  • Title: [Macrophage activation syndrome: a diagnostic challenge].
    Author: Soult Rubio JA, García Bernabeu V, Sánchez Alvarez MJ, Muñoz Sáez M, López Castilla JD, Tovaruela Santos A.
    Journal: An Esp Pediatr; 2002 Feb; 56(2):165-7. PubMed ID: 11827655.
    Abstract:
    Macrophage activation syndrome, or hemophagocytic syndrome, is a rare disease with high morbidity and mortality. It is a disorder of the mononuclear phagocyte system. Two forms have been described; primary or familial hemophagocytic lymphohistiocytosis and secondary or sporadic hemophagocytic syndrome. Diagnosis of macrophage activation syndrome poses a real challenge for the pediatrician and in many cases is only made at autopsy. We describe two patients with hemophagocytic syndrome associated with parvovirus B19 and Epstein-Barr virus infection.
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