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  • Title: Novel functionalized pyrido[2,3-g]quinoxalinones as antibacterial, antifungal and anticancer agents.
    Author: Carta A, Sanna P, Gherardini L, Usai D, Zanetti S.
    Journal: Farmaco; 2001 Dec; 56(12):933-8. PubMed ID: 11829113.
    Abstract:
    A series of twelve novel pyrido[2,3-g]quinoxalinones (3-14), variously substituted at the C-3 position, was synthesized, structurally determined and submitted to a preliminary in vitro evaluation for antibacterial, anticandida and anticancer activities. Results of the antimicrobial screening showed that all compounds, with the exception of 6, 11 and 12, exhibited interesting activity against all strains tested; while compound 10 was found to have encouraging in vitro anticancer activity at a concentration of l0(-4) M.
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