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  • Title: [Diagnosis and treatment of familial adenomatous polyposis].
    Author: Li Y, Song S, Jiang Y.
    Journal: Zhonghua Wai Ke Za Zhi; 1999 Jun; 37(6):328-30. PubMed ID: 11829850.
    Abstract:
    OBJECTIVE: To summarize the experience with diagnosis and therapy of familial adenomatous polyposis (FAP). METHODS: Thirteen patients with FAP who had undergone total colectomy were analyzed retrospectively. RESULTS: In 5 patients with benign and 8 patients with malignant adenomatous polyposis, their average age at operation was 31.5 years (range 10 - 57), 25 years in benign patients and 36 years in malignant patients. Familial inherited histories were found in 8 patients in 6 families. Nineteen patients were determined in 6 families in 3 generations. Seven familial members died of colorectal cancer in 4 families. History lasted 2 - 20 years. The number of adenomatous polyposis was more than 100. All patients underwent total colectomy, ileostomy or anus-preserving surgery with or without ileal pouch. All patients without canceration survived. The longest one exceeded 25 years, but 3/8 patients with canceration developed metastasis of liver, brain and abdomen within 6 months after surgery. CONCLUSIONS: FAP will turn to be cancer if not removed. Total colectomy or proctocolectomy should be performed before canceration. Total colectomy, preserving muscular sheath of the rectum after mucosectomy, ileal pouch-anal anastomosis may be the operative choice for FAP.
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