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  • Title: [Detection of telomerase activity in prostate needle-biopsy samples].
    Author: Wang X, Zhang Y, Ding Q, Ye L, Zhai L, Jia W.
    Journal: Zhonghua Wai Ke Za Zhi; 1999 Dec; 37(12):762-4. PubMed ID: 11829949.
    Abstract:
    OBJECTIVE: To detect telomerase activity inprostate needle-biopsy samples and its role in diagnosis and prognosis of prostate cancer. METHODS: 20 tissue samples of prostate cancer tissues and 16 samples of adjacent tissues were obtained by needle-biopsy guided by transrectal B ultrasonography. 16 samples of benign prostatic hyperplasia tissues were obtained by prostatectomy and were confirmed pathologically. Telomerase activity was revealed by modified PCR-based telomeric repeat amplication protocol (TRAP)-silver staining assay. RESULTS: Telomerase activity was revealed in 18 cases of prostate cancer. In tissues adjacent to prostate cancer, telomerase activity was found in 7 of 11 cases of prostatic intraepithelial neoplasia (PIN), and in 2 of 5 cases of BPH. None of tissue samples from patients with BPH showed telomerase activity. CONCLUSIONS: Telomerase activity in prostate needle-biopsy samples might be an useful marker for detecting prostate cancer and biological malignancy.
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