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  • Title: An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis.
    Author: Mazmanian SK, Ton-That H, Su K, Schneewind O.
    Journal: Proc Natl Acad Sci U S A; 2002 Feb 19; 99(4):2293-8. PubMed ID: 11830639.
    Abstract:
    Sortase (SrtA), an enzyme that anchors surface proteins to the cell wall of Gram-positive bacteria, cleaves sorting signals at the LPXTG motif. We have identified a second sortase (SrtB) in the Gram-positive pathogen Staphylococcus aureus that is required for anchoring of a surface protein with a NPQTN motif. Purified SrtB cleaves NPQTN-bearing peptides in vitro, and a srtB mutant is defective in the persistence of animal infections. srtB is part of an iron-regulated locus called iron-responsive surface determinants (isd), which also contains a ferrichrome transporter and surface proteins with NPQTN and LPXTG motifs. Cell wall-anchored surface proteins and the isd locus seem involved in a novel mechanism of iron acquisition that is important for bacterial pathogenesis.
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