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  • Title: [Measurement of T and DHT contents in normal and diseased human prostate tissues].
    Author: Zhang Y, Ye L, Ding Q, Fang Z, Yao M, Shi D.
    Journal: Zhonghua Wai Ke Za Zhi; 2000 Jul; 38(7):545-7. PubMed ID: 11832106.
    Abstract:
    OBJECTIVE: To measure T and DHT contents in normal and diseased human prostate tissues. METHODS: Serum and prostatic T and DHT levels were measured in patients with normal, benign prostatic hyperplasia and prostate cancer. RESULTS: A decline was observed in serum T level, but no change in DHT concentration with aging. There were no significant differences in both blood T and DHT levels between the patients with BPH or PCA and normal controls. Serum T level remained constant. There were excessive accumulation of DHT in BPH, and cancerous prostate tissues were responsible for the pathogenesis of BPH and PCA. Finasteride treatment did not produce a reduction in prostatic DHT content. CONCLUSION: More than one form of 5a-reductases is responsible for the high level of DHT in the gland.
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