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  • Title: The role of PML in tumor suppression.
    Author: Salomoni P, Pandolfi PP.
    Journal: Cell; 2002 Jan 25; 108(2):165-70. PubMed ID: 11832207.
    Abstract:
    The PML gene, involved in the t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL), encodes a protein which localizes to the PML-nuclear body, a subnuclear macromolecular structure. PML controls apoptosis, cell proliferation, and senescence. Here, we review the current understanding of its role in tumor suppression.
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