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  • Title: De novo expression of calretinin in trimethyltin-induced degeneration of developing rat hippocampus.
    Author: Businaro R, Corvino V, Geloso MC, De Santis E, Fumagalli L, Michetti F.
    Journal: Brain Res Mol Brain Res; 2002 Jan 31; 98(1-2):141-4. PubMed ID: 11834306.
    Abstract:
    In the model of trimethyltin (TMT)-induced neurodegeneration in developing rat hippocampus, calretinin (CR)-immunoreactive neurons are selectively spared and even more numerous than in controls. We investigated the possibility of an additional synthesis of CR using RT-PCR. The amount of CR mRNA increased significantly after TMT treatment. CR mRNA production after TMT treatment could hypothetically be regarded as a compensatory phenomenon in developing rats.
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