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  • Title: Yeast-mediated preparation of l-PAC in an organic solvent.
    Author: Kostraby MM, Smallridge AJ, Trewhella MA.
    Journal: Biotechnol Bioeng; 2002 Mar 30; 77(7):827-31. PubMed ID: 11835143.
    Abstract:
    The yeast-mediated acyloin condensation of benzaldehyde and pyruvic acid to form l-PAC occurs in a petroleum spirit solvent system at room temperature with moderate conversion (30%) and high enantioselectivity (86%ee) after 24 h. The addition of a small amount of ethanol (0.5% mL) to the reaction mixture inhibits the formation of the side product benzyl alcohol and increases the conversion to l-PAC. Conducting the reaction using 13C labeled pyruvate indicated that the pyruvate was incorporated into the l-PAC and that the excess pyruvate was converted into ethanol. Conducting the reaction at 5 degrees C results in similar conversion but higher enantioselectivity.
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