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  • Title: [The immunohistochemical changes of TGF-beta, type I and III collagen in corneal healing after photorefractive keratectomy].
    Author: Qi Y, Lian J, Wang K, Wang Y.
    Journal: Zhonghua Yan Ke Za Zhi; 1999 Jul; 35(4):274-6, 15. PubMed ID: 11835821.
    Abstract:
    OBJECTIVE: To observe the immunohistochemical expression of transforming growth factor-beta (TGF-beta), type I and III collagen in monkey corneal healing after photorefractive keratectomy (PRK) and find whether TGF-beta is involved in the process of corneal healing and correlated with the syntheses of type I and III collagen. METHODS: Three rhesus monkeys (6 eyes) were operated for myopic ablation of 10.0 diopters. The depth of ablation was 103 microm. Microscopy, transmission electron microscopy and immunohistochemistry were performed at 1, 3 and 6 months after PRK. RESULTS: TGF-beta staining was positive in the epithelium and a few fibroblasts under the epithelium at one month after the operation. The staining was negative at 6 months and in the control specimens. Postoperatively, type I and III collagen stainings were evident at 1, 3 and 6 months. Type I collagen staining was positive and type III was negative in the controls. CONCLUSION: TGF-beta is involved in the corneal healing after PRK, and perhaps correlated with the syntheses of type I and III collagen.
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