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  • Title: [Effect of bFGF, IGF-I and their synergy on the mitogenesis of bovine lens epithelial cells].
    Author: Sun Z, Yao K, Wu R, Shentu X, Xu W.
    Journal: Zhonghua Yan Ke Za Zhi; 1999 Nov; 35(6):462-4. PubMed ID: 11835863.
    Abstract:
    OBJECTIVE: To assess the effect of basic fibroblast growth factor (bFGF), insulin like growth factor-I (IGF-I) and their synergy on the mitosis of bovine lens epithelial cells (BLECs). METHODS: BLECs were cultured in vitro. The fourth passage cells were inoculated into 24 well tissue culture plates, treated with different concentrations of bFGF, IGF-I, and bFGF + 20 microg/L IGF-I for 20 hours, (3)H-thymidine was added for 16 hours, then the radioactivity was determined by liquid scintillation counting. RESULTS: Either bFGF (1 - 100 microg/L) or IGF-I (20 - 100 microg/L) increases mitosis of BLEC significantly, and 20 microg/L IGF-I may increase bFGF induced mitogenesis. CONCLUSION: Growth factor and their synergic effect may play an important role in lens epithelial cell proliferation.
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