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  • Title: [Evaluation of the skin resorptive action of testosterone and its esters].
    Author: Fedorov VK, Shashkina LF.
    Journal: Farmakol Toksikol; 1975; 38(5):596-9. PubMed ID: 1183593.
    Abstract:
    The skin-resorptive action of testosterone and of its ethers (propionate, phenylpropionate, isocapronate, enantate, caprinate) was studied on castrated albino male rats with a one-time application to the skin. The effect was assessed by the growth of the seminal vesicles and the ventral lobe of the prostate. The highest skin-resorptive activity displayed testosterone-propionate and the lowest--testosterone-caprinate. The maximum effect following application of all the studied substances was registered on the 2-3d day. The amount of the maximum active dose (0,1 mg per animal) warrants including these compounds in a group of highly dangerous substances producing a skin-resorptive action.
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