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  • Title: Suppression of tumor growth and pulmonary metastasis in murine osteosarcoma using gene therapy.
    Author: Seto M, Yamazaki T, Sonoda J, Matsumine A, Shinto Y, Uchida A.
    Journal: Oncol Rep; 2002; 9(2):337-40. PubMed ID: 11836603.
    Abstract:
    We evaluated the effect of gene therapy in the murine osteosarcoma cell line, LM8, which preferentially metastasizes to the lungs. LM8 cells were transduced with the gene for a herpes simplex virus thymidine kinase (HSV-tk) or Escherichia coli beta-galactosidase (lacZ). We investigated the cytotoxicity of LM8 cells bearing an HSV-tk gene after treatment with ganciclovir (GCV). LM8 cells bearing an HSV-tk gene were more sensitive than non-transduced cells. The remarkable inhibition of tumor growth and pulmonary metastases was confirmed in vivo. Our findings indicated that GCV kills tumor cells transduced with HSV-tk in vitro and in vivo.
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