These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Analysis on point mutation of the CDKN2/p16 gene in lung cancer].
    Author: Su C, Ye Y, Wang D, Cao X, Li S, Shan X.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2002 Feb; 19(1):37-40. PubMed ID: 11836684.
    Abstract:
    OBJECTIVE: To study the status of CDKN2/p16 gene point mutation in lung cancer. METHODS: Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and sequencing were used to detect the point mutation of CDKN2/p16 gene exon 2 in 89 cases of lung cancer. RESULTS: In 69 cases of the lung cancer without deletion of CDKN2/p16 gene exon 2, 16 cases were found to have suspicious abnormality of CDKN2/p16 gene exon 2 by PCR-SSCP, and in these 16 cases, 9 were found to harbor point mutations of CDKN2/p16 gene exon 2 by automated sequencing analysis. CONCLUSION: The point mutation is one of the mechanisms for CDKN2/p16 gene inactivation, but it is not the chief mechanism. The inactivation of CDKN2/p16 gene aroused by point mutation plays a role to some extent in the genesis and progression of lung cancer.
    [Abstract] [Full Text] [Related] [New Search]