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  • Title: [Response of keloid fibroblasts to the effect of tumor necrosis factor-alpha(TNF-alpha)].
    Author: He W, Liu R, Zhong B.
    Journal: Zhonghua Zheng Xing Wai Ke Za Zhi; 2001 Nov; 17(6):332-4. PubMed ID: 11838052.
    Abstract:
    OBJECTIVE: To investigate the biologic behavior of keloid fibroblasts and the pathogenesis of keloid. METHODS: Human dermal fibroblasts cultured from normal skin and keloid were treated with tumor necrosis factor-alpha(TNF-alpha) for 48 hours at 10(3) U/ml and 10(4) U/ml. Collagen production by fibroblasts was assessed by 3H-proline in corporation into pepsin-resistant, precipitated extracellular collagenous protein. RESULTS: TNF-alpha caused a concentration-dependent reduction in collagen production in normal dermal fibroblasts. Treatment with TNF-alpha at 10(3) U/ml significantly reduced the collagen synthesis in keloid fibroblasts (P < 0.01). However, the collagen synthesis in keloid fibroblasts did not further decreased after exposure to TNF-alpha at 10(4) U/ml. CONCLUSIONS: Keloid fibroblasts may remain less sensitive to the inhibitory effects of TNF-alpha on collagen synthesis to a certain extent.
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