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  • Title: The regulation and function of the Id proteins in lymphocyte development.
    Author: Rivera R, Murre C.
    Journal: Oncogene; 2001 Dec 20; 20(58):8308-16. PubMed ID: 11840323.
    Abstract:
    Helix-loop-helix (HLH) proteins are essential factors for lymphocyte development and function. One class of HLH proteins, the E-proteins, regulate many aspects of lymphocyte maturation, survival, proliferation, and differentiation. E-proteins are negatively regulated by another class of HLH proteins known as the Id proteins. The Id proteins function as dominant negative inhibitors of E-proteins by inhibiting their ability to bind DNA. Here we discuss the function and regulation of the Id proteins in lymphocyte development.
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