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  • Title: New findings in the chromosome 13 long-arm deletion syndrome and retinoblastoma.
    Author: Weichselbaum RR, Zakov ZN, Albert DM, Friedman AH, Nove J, Little JB.
    Journal: Ophthalmology; 1979 Jun; 86(6):1191-201. PubMed ID: 118416.
    Abstract:
    New clinical and pathologic findings in patients with deletion of the long arm of chromosome 13 (13q-) include optic nerve hypoplasia and retinal dysplasia. Fibroblasts derived from patients with a 13q- syndrome with and without retinoblastoma, as well as from familial and sporadic retinoblastoma, are a useful model for the study of genetic susceptibility to the development of spontaneous and radiation-induced cancers. Fibroblasts from patients with hereditary retinoblastoma appear more radiosensitive than fibroblasts from patients with sporadic retinoblastoma or normal control patients.
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