These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Ontogenetic expression and regulation of Na(+)-D-glucose cotransporter in jejunum of domestic chicken.
    Author: Barfull A, Garriga C, Mitjans M, Planas JM.
    Journal: Am J Physiol Gastrointest Liver Physiol; 2002 Mar; 282(3):G559-64. PubMed ID: 11842007.
    Abstract:
    To evaluate the effect of age on sugar transport, we determined the uptake of methyl alpha-D-glucopyranoside and the abundance of the Na(+)-D-glucose cotransporter (SGLT1) in jejunal brush-border membrane (BBM) vesicles of 2-day- and 5-wk-old chickens. Methyl alpha-D-glucopyranoside transport per BBM protein was 40% lower in adults than in newly hatched chickens. This finding was matched by parallel declines in site density of SGLT1, which were detected by Western blot. The immunohistochemical study showed that SGLT1 was exclusively located in the BBM of enterocytes along the entire villus and was absent in the crypt in both age groups, and there was an 11-fold increase in the total absorptive area during development. Northern blot studies of the abundance of SGLT1 mRNA showed similar levels for the groups studied. We conclude that the age-related decline in Na(+)-dependent hexose transport per unit of BBM protein in the chicken jejunum is due to a reduction in the density of SGLT1 cotransporter and is regulated by a posttranscriptional mechanism.
    [Abstract] [Full Text] [Related] [New Search]