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  • Title: Antioxidant effects of 1,5-anhydro-D-fructose, a new natural sugar, in vitro.
    Author: Yamaji K, Sarker KP, Maruyama I, Hizukuri S.
    Journal: Planta Med; 2002 Jan; 68(1):16-9. PubMed ID: 11842320.
    Abstract:
    The antioxidant effects of 1,5-anhydro-D-fructose (1,5-AF), a unique anhydrohexulose, were studied in 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution, in human cells along with lipid peroxidation of low-density lipoprotein (LDL). We have confirmed that 1,5-AF scavenges DPPH radicals directly in solution and inhibits the formation of hydrogen peroxide and superoxide anion, typical reactive oxygen species (ROS), induced by phorbol myristate acetate (PMA) in a dose-dependent manner in THP-1 cells. We also observed the dose-dependent antioxidant effects of 1,5-AF on copper-mediated LDL oxidation. These findings suggest that 1,5-AF might play a role in reducing the risk of atherosclerosis and may help prevent coronary heart disease.
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