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  • Title: Cushing's syndrome associated with a bronchial adenoma. Possible periodic hormonogenesis.
    Author: Shapiro MS, Gutman A, Bruderman I, Myers B, Griffel WB.
    Journal: Isr J Med Sci; 1975 Sep; 11(9):919-24. PubMed ID: 1184365.
    Abstract:
    Diagnostic and therapeutic problems in a patient with ectopic ACTH syndrome caused by a malignant bronchial adenoma are discussed. Persistent Cushing's syndrome was present following apparent total adrenalectomy, but radioactive scanning with 131I-19-iodocholesterol showed the presence of residual adrenal tissue in the right suprarenal bed. Amelioration of the hypercortisolism occurred after removal of the bronchial adenoma. A paradoxical elevation of adrenocortical activity followed administration of dexamethasone and data are presented which suggest that periodic secretion of ACTH accounted for this phenomenon.
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