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  • Title: Potentiated antitumor effects of interleukin 12 and interferon alpha against B16F10 melanoma in mice.
    Author: Dabrowska A, Giermasz A, Gołab J, Jakóbisiak M.
    Journal: Neoplasma; 2001; 48(5):358-61. PubMed ID: 11845979.
    Abstract:
    Systemic administration of cytokines has not found broad application in cancer immunotherapy due to its toxicity and lack of effectiveness in a broad spectrum of tumors. Among the most promising cytokines used often in pre-clinical and clinical trials are interferon alpha and interleukin 12. We have shown in our study that combining IL-12 with IFN-alpha in a dose which alone does not show antitumor activity results in potentiated antitumor effects without inducing toxicity.
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