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  • Title: Microbial epoxide hydrolases for preparative biotransformations.
    Author: Steinreiber A, Faber K.
    Journal: Curr Opin Biotechnol; 2001 Dec; 12(6):552-8. PubMed ID: 11849937.
    Abstract:
    Epoxide hydrolases from microbial sources are highly versatile biocatalysts for the asymmetric hydrolysis of epoxides on a preparative scale. Besides kinetic resolution, which furnishes the corresponding vicinal diol and remaining non-hydrolysed epoxide in nonracemic form, enantioconvergent processes are possible: these are highly attractive as they lead to the formation of a single enantiomeric diol from a racemic oxirane. The data accumulated over recent years reveal a common picture of the substrate structure selectivity pattern of microbial epoxide hydrolases and indicate that substrates of various structural types can be selectively hydrolysed with enzymes from certain microbial sources.
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