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  • Title: Optimal dose of amoxicillin in treatment of otitis media caused by a penicillin-resistant pneumococcus strain in the gerbil model.
    Author: Parra A, Ponte C, Cenjor C, García-Calvo G, Giménez MJ, Aguilar L, Soriano F.
    Journal: Antimicrob Agents Chemother; 2002 Mar; 46(3):859-62. PubMed ID: 11850273.
    Abstract:
    Amoxicillin at doses of 0.2 to 5 mg/kg of body weight was administered for the treatment of pneumococcal otitis media in a gerbil model. Doses greater than or equal to 2.5 mg/kg, which resulted in concentrations in middle ear fluid of > or = 1.4 microg/ml and concentrations in serum higher than the MIC (1 microg/ml) for > or = 14% of the dosing interval, were both clinically and bacteriologically effective.
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