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  • Title: [Relationship between epidemiology of HIV-1 infection and HIV-1 subtypes in Fujian province].
    Author: Yan Y, Weng Y, Chen G.
    Journal: Zhonghua Liu Xing Bing Xue Za Zhi; 2001 Dec; 22(6):428-31. PubMed ID: 11851056.
    Abstract:
    OBJECTIVE: To explore the relationship of AIDS epidemic and HIV-1 subtype in Fujian province of China based on molecular findings. METHODS: HIV-1 infected persons and patient with AIDS (HIV/AIDS) were identified by AIDS surveillance project in the province. AIDS epidemic situation was estimated by related data collected from the HIV/AIDS cases. HIV-1 C2-V3 region amplified from the PBMC DNA of HIV/AIDS cases was analysed by nucleotide sequencing to identified HIV-1 subtype. RESULTS: One hundred and eighty-eight cases of HIV/AIDS were found from 1987 to the end of 2000. Among 59 AIDS cases, 53 had died. HIV infection through heterosexual contacts took up 65.4%, including 44.1% of them infected abroad. Out of them, 83.1% were infected in Southeast Asia. Thirty-nine point nine percentage of the total HIV(+) were infected in China, while 9.0% were infected through blood transmission. Sequence analysis from 41 specimens showed that there were 4 kinds of HIV-1 subtypes, including A, B, C and E. Subtype E took up 75.6% (31/41), all infected by heterosexual contacts; subtype B taking up 17.1% (7/41) with most of them infected through blood transmission; subtype A and C were seen only 1 and 2 cases respectively. Gene divergence of innergroup of subtypes E was 12.245% +/- 3.894%, while subtype B was 10.762% +/- 2.707%. The high divergence of subtype E could be attributed to the region and time of infection. CONCLUSION: HIV prevalent rate has been increasing in Fujian with major transmission route of heterosexual contact. The dominant strain of HIV-1 was subtype E.
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