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  • Title: Partial selectivity of 6-OHDA induced neuronal degeneration after intraissular injection in the brain with special reference to the nigro-striatal dopamine system.
    Author: Javoy F.
    Journal: J Neural Transm; 1975; 37(3):219-27. PubMed ID: 1185167.
    Abstract:
    The selectivity of 6-OHDA induced neuronal degeneration after intra-tissular injection in the brain is discussed considering the morphological and biochemical events occurring in the substantia nigra and in the striatum--after intranigral or intrastriatal application of the drug. The data suggest that a critical intratissular concentration of 6-OHDA is required to induce an elective neuronal degeneration. The importance of the non-specific damage can not be neglected when high doses of the drug are administered in the brain tissue.
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