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  • Title: Effects of heroin and methadone on plasma cortisol and testosterone.
    Author: Mendelson JH, Meyer RE, Ellingboe J, Mirin SM, McDougle M.
    Journal: J Pharmacol Exp Ther; 1975 Nov; 195(2):296-302. PubMed ID: 1185598.
    Abstract:
    Narcotic addicts self-administered heroin intravenously for 10 days under controlled research ward conditions and were subsequently detoxified with methadone for 7 days. Plasma testosterone levels decreased signifcantly when heroin dosage was between 45 and 65 mg/day contrasted to predrug base-line levels. Testosterone levels remained depressed during methadone withdrawal. No statistically significant changes in a.m. plasma cortisol levels were observed during both heroin acquisition and methadone withdrawal.
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