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  • Title: Hospital-acquired salicylate intoxication. report of a case with psychosis, acidosis, and coma.
    Author: Good AE, Welch MH.
    Journal: J Rheumatol; 1975 Mar; 2(1):52-60. PubMed ID: 1185735.
    Abstract:
    A case of salicylate intoxication from repeated therapeutic doses of aspirin is reported in an adult with impairment of salicylate elimination. Evolution of acid-base disturbance from respiratory alkalosis to metablic acidosis is documented. Serum salicylate levels during several years of therapy demonstrate the acquisition of impaired elimination of the drug. This case illustrates the practical importance of special features of salicylate accumulation kinetics emphasized in a recent review.
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