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  • Title: Nonspecific inhibition of DNA repair by promoting and nonpromoting phorbol esters.
    Author: Langenbach R, Kuszynski C.
    Journal: J Natl Cancer Inst; 1975 Oct; 55(4):801-2. PubMed ID: 1185805.
    Abstract:
    The effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and its nonpromoting structural analogue, 4-O-methyl-12-O-tetradecanoylphorbol-13-acetate (Me-TPA), on N-acetoxy-2-acetylaminofluorene-elicited DNA repair and replicative DNA synthesis was measured in normal human fibroblasts. Both esters inhibited DNA repair synthesis, and Me-TPA was nearly as effective as TPA. In addition, TPA inhibited replicative DNA synthesis. These findings showed that inhibition of DNA repair synthesis may not be a major factor in the mechanisms of action of tumor promoters.
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