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  • Title: Developmental pharmacology and the Ah locus: regulatory and temporal genes affecting teratogenesis.
    Author: Nebert DW, Shum S, Boobis AR, Atlas SA.
    Journal: Acta Biol Med Ger; 1979; 38(4):519-29. PubMed ID: 118606.
    Abstract:
    The "Ah cluster" is a group of regulatory, temporal, and structural genes associated with the inducibility of numerous monooxygenase activities by polycyclic aromatic compounds such as 3-methylcholanthrene. Age- and tissue-specific differences in temporal control of these enzymes are shown to exist. These differences could be important in the age- and tissue-specific differences in one's susceptibility to cancer, drug toxicity, and birth defects. Allelic differences at the Ah locus are shown in the mouse to be associated with benzo[a]-pyrene-produced in utero toxicity: increased stillborns, resorptions, and dysmorphogenesis, plus decreased fetal weight.
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