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  • Title: [Preventive effects of three kinds of inactive vaccines against epidemic hemorrhagic fever (EHF) after 5 years of vaccination].
    Author: Chen H, Tang L, Luo Z, Zhang J, Zhang Z, Hu M, Weng J, Liu W, Zhao T, Liu W.
    Journal: Zhonghua Liu Xing Bing Xue Za Zhi; 2000 Oct; 21(5):347-8. PubMed ID: 11860813.
    Abstract:
    OBJECTIVE: To observe the safety and the preventive effects of three kinds of vaccines as Mongolian gerbils kidney vaccine, mouse brains vaccine and hamster kidney vaccine inoculated 5 years ago. METHODS: Field study and laboratory tests were carried out by random grouping and IFAT, MCPENT, ELISA, HI tests. RESULTS: The antibody-dependent enhancement did not appear in all individuals who received vaccines after four or five years. The seroconversion rates of MCPENT were 8.97%, 11.76% and 18.75% while the seroconversion rates of IFAT were 20.73%, 30.22% and 23.40% respectively for Mongolian gerbils kidney vaccine, mouse brains vaccine and hamster kidney vaccine. The protection rates were 100% for all three kinds of inactive vaccines which showed good epidemiological efficacy. CONCLUSION: The vaccines can protect clinical infection of EHF effectively after four or five years of the initial vaccination.
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