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  • Title: [Seroepidemiological analysis of characteristic of hepatitis B virus in children after vaccination in Ningbo].
    Author: Chen H, Zhou A, Wang R.
    Journal: Zhonghua Liu Xing Bing Xue Za Zhi; 2001 Jun; 22(3):184-7. PubMed ID: 11860873.
    Abstract:
    OBJECTIVE: To understand the immunity of children in Ningbo after hepatitis B vaccination for seven years and to explore the best time for booster. METHODS: One thousand nine hundred and twenty serum samples from children born in 1982 - 1995 were tested for anti-HBs and HBsAg, using RIA. RESULTS: (1) HBsAg positive rate (2.66%) was lower in vaccinated children born in 1992 - 1995 than those unvaccinated (10.92%) born in 1982 - 1995. HBsAg positive rate had a drop of 75.71% (chi(2) = 22.91, P < 0.0001). (2) Anti-HBs positive rates (65.95%) in vaccinated children was much higher than that in unvaccinated children (41.03%) (chi(2) = 113.67, P < 0.0001). (3) It also showed that children's positive rate of HBsAg increased and anti-HBs dropped after 5 - 7 years of vaccination. CONCLUSION: After immunization of hepatitis B vaccine for 7 years, high immunity and low infection rate of HB in children it appeared in Ningbo. However it is necessary to further study the reason causing the increase of HBsAg positive rate and/or deerease of anti-HBs positive rate, and the suitable time frame of boostering, after 4 or 5 years of primary vaccination.
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