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  • Title: [Study on the protective effect of grape procyanidins on DNA damage induced by irradiation].
    Author: Li S, Zhong J, Sun F.
    Journal: Zhonghua Yu Fang Yi Xue Za Zhi; 2000 May; 34(3):131-3. PubMed ID: 11860916.
    Abstract:
    OBJECTIVE: To study the protective effect of grape procyanidins (GPC) on the irradiated DNA damage. METHOD: In vivo study: After orally administration of GPC, mice in different groups were exposed to whole-body (60)Co gamma-rays at a dose of 2.0 Gy and the fluorospectrometry method was used to rapidly detect the DNA strand breaks of mouse spleen cells. In vitro study: Human venous blood with different concentrations of GPC was exposed to (60)Co gamma-rays at a dose of 1.0 Gy, then WBC DNA content was measured after 1, 30 and 60 min exposure, respectively. RESULTS: In the three treated groups (500, 250 and 50 mg/kg of procyanidins), DNA content of mouse spleen cells was 18.76%, 15.74% and 5.06% more than that of the positive controls respectively. DNA content of human WBC was higher than the positive controls by 17.6%, 11.1% and 3.9% increase respectively one minute after irradiation and 21.3%, 13.8% and 5.3% increase respectively 60 min after irradiation. These differences were all statistically significant. CONCLUSION: GPC has a protective effect on DNA damage caused by irradiation, and is helpful to DNA repair.
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