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  • Title: Adenovirus and ileocecal intussusception.
    Author: Yunis EJ, Atchison RW, Michaels RH, DeCicco FA.
    Journal: Lab Invest; 1975 Oct; 33(4):347-51. PubMed ID: 1186117.
    Abstract:
    Intranuclear inclusion bodies were found by light microscopy in epithelial cells in more than one-third of the specimens from children operated on for ileocecal intussusception. Electron microscopic examination done on hematoxylin and eosin-stained slides showed the intranuclear inclusion bodies to be composed of viral particles in large and small crystalline arrays. Adenovirus of serotypes 2, 3, and 5 were isolated from the five cases with inclusions in which isolation was attempted. These findings strongly suggest a pathogenetic role for adenovirus in those cases of intussusception in which intranuclear inclusion bodies are found in the epithelial cells of the appendix or the terminal ileum.
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