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  • Title: Deamination of biogenic amines and other nitrogenous compounds in granulation tissue from experimental wounds.
    Author: Romanova LA, Stalnaya ID, Gorkin VZ.
    Journal: Med Biol; 1975 Aug; 53(4):205-9. PubMed ID: 1186318.
    Abstract:
    In the granulation tissue of skin wounds an increase in the content of hydroxyproline was accompanied by changes in lipid peroxidation products. At the same time deamination of 5-hydroxytryptamine, tyramine or adenosine-5'-monophosphate decreased, but the ability to deaminate histamine, putrescine and lysine appeared. Pargyline prevented the appearance of these new deaminating properties. Adenosine-3'-monophosphate slowed down to the weight increase and lowered the content of hydroxyproline in the growing granulation tissue; it also changed the dynamics of deamination of tyramine or 5-hydroxytryptamine and significantly inhibited the deamination of histamine, lysine and adenosine-5'-monophosphate. The patterns of changes in deamination of nitrogenous compounds and the effects caused by pargyline and adenosine-3'-monophosphate suggest that qualitative alteration (transformation) in catalytic properties of monoamine oxidases may occur in the growing granulation tissue from wounds.
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