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  • Title: [Effects of fasting on expression of insulin-like growth factor-I and IGF binding protein-1 genes in the liver of rats].
    Author: Li Q, Bréat B, Czernichow P.
    Journal: Zhonghua Yu Fang Yi Xue Za Zhi; 1999 Sep; 33(5):289-91. PubMed ID: 11864494.
    Abstract:
    OBJECTIVE: To investigate the molecular mechanisms of body development and growth regulated by nutritional status. METHODS: Effects of fasting on the expression of insulin-like growth factor-I (IGF-I) and IGF binding protein-1 (IGFBP-1) genes were analyzed by Northern blotting technique in rats. RESULTS: Fasting for 48 hours, body weight of the rats decreased by 11.8%, level of blood glucose by 50.8% and content of IGF-I mRNA in the liver by 32.7% (P < 0.05). On the contrary, content of IGFBP-1 mRNA in the liver of fasted rats increased gradually, with a 2.5 time increase after 24 h fasting (P < 0.05). There was no significant change in the level of liver albumin mRNA after fasting. CONCLUSION: Fasting could inhibit the expression of IGF-I gene and enhance the expression of IGFBP-1 gene.
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