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  • Title: Role of K+ channels in the PACAP-induced catecholamine secretion from the rat adrenal gland.
    Author: Fukushima Y, Nagayama T, Hikichi H, Mizukami K, Yoshida M, Suzuki-Kusaba M, Hisa H, Kimura T, Satoh S.
    Journal: Eur J Pharmacol; 2002 Feb 15; 437(1-2):69-72. PubMed ID: 11864641.
    Abstract:
    We eluciated whether K+ channels modulate adrenal catecholamine secretion induced by pituitary adenylate cyclase-activating polypeptide (PACAP) in the isolated perfused rat adrenal gland. PACAP (100 nM) increased adrenal epinephrine output. The PACAP-induced responses were enhanced by treatment with apamin (10-100 nM) in a concentration-dependent manner. In the presence of nifedipine (3 microM), apamin (1 microM) did not enhance the PACAP-induced responses. Charybdotoxin (1-100 nM) had little influence on the PACAP-induced responses. These results suggest that small-conductance Ca2+-activated K+ channels interfere with L-type voltage-dependent Ca2+ channels to counteract the PACAP-induced adrenal catecholamine secretion.
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