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  • Title: Antidiarrhoeal activity of Strychnos potatorum seed extract in rats.
    Author: Biswas S, Murugesan T, Sinha S, Maiti K, Gayen JR, Pal M, Saha BP.
    Journal: Fitoterapia; 2002 Feb; 73(1):43-7. PubMed ID: 11864763.
    Abstract:
    The antidiarrhoeal activity of the methanol extract of the dried seeds of Strychnos potatorum (MESP) has been evaluated out in rats using different models (castor oil-induced diarrhoea, effects on gastrointestinal motility and on PGE(2)-induced gastric enteropooling. MESP (100, 200 and 400 mg/kg, p.o.) significantly (P<0.001) inhibited the frequency of defaecation and reduced the wetness of faecal droppings in castor oil-induced diarrhoea, decreased the propulsion of charcoal meal through the gastrointestinal tract, and also reduced the PGE(2)-induced enteropooling.
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