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  • Title: [The clinical effect of TS-1 in advanced and recurrent gastric cancer with peritoneal dissemination].
    Author: Inaba Y, Watabe S, Ohe S, Kamio Y, Koyama M, Hayashi K, Chiba M.
    Journal: Gan To Kagaku Ryoho; 2002 Feb; 29(2):239-44. PubMed ID: 11865630.
    Abstract:
    Eighteen patients with far advanced and recurrent gastric cancer with peritoneal dissemination were treated with a novel oral anticancer drug, TS-1, and assessed according to clinical effect. TS-1 was administered at a dose of 80-120 mg/day. One course consisted of consecutive administration of TS-1 for 28 days followed by 14 days rest. The 1- and 2-year survival rates and median survival time after administration of TS-1 were 63.2%, 23.7% and 437 days, respectively. Eight patients (44.4%) survived for 1 year or more. Adverse reactions consisted of reduction in hemoglobin level and hyperbilirubinemia at grades 3 and 4, which were observed in 3 patients and 1 patient, respectively. TS-1 is a promising drug for gastric cancer with peritoneal dissemination.
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