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  • Title: NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells.
    Author: Xie Y, Chen C, Stevenson MA, Hume DA, Auron PE, Calderwood SK.
    Journal: Biochem Biophys Res Commun; 2002 Mar 08; 291(4):1071-80. PubMed ID: 11866474.
    Abstract:
    We have examined the functional antagonism between the regulator of the heat shock response, HSF1, and NF-IL6, which plays a major role in control of the acute phase response (APR). Agents that activate HSF1 such as heat shock and sodium salicylate inhibit NF-IL6 induced transcription while NF-IL6 activators such as lipopolysaccharide (LPS) and interleukin 6 (IL-6) repressed the stress responsive HSP70B promoter. In transfection studies, the inhibitory effects of HSF1 and NF-IL6 on the c-fms promoter were shown to be highly dose-dependent. Furthermore, heat shock is inhibitory to differentiation-linked expression of macrophage colony stimulating factor (M-CSF) receptor, product of the c-fms gene, which is transcriptionally activated by NF-IL6 but repressed by HSF1. Our studies suggest a strong mutual antagonism between the heat shock response and APR, which may influence the sensitivity and duration of inflammatory responses.
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