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  • Title: Regulation of cell cycle stage-specific transcription of histone genes from chromatin by non-histone chromosomal proteins.
    Author: Stein G, Park W, Thrall C, Mans R, Stein J.
    Journal: Nature; 1975 Oct 30; 257(5529):764-7. PubMed ID: 1186855.
    Abstract:
    RNA transcripts from chromatin of S phase but not G1 cells contain histone-specific sequences. Chromatin reconstituted with S phase non-histone chromosomal proteins transcribes histone messenger RNA sequences whereas chromatin reconstituted with G1 non-histone proteins does not. These results suggest that transcription of histone genes is regulated during the cell cycle and that non-histone proteins have a key role in this regulation.
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